CNS organoids: an innovative tool for neurological disease modeling and drug neurotoxicity screening

The paradigm of central nervous system (CNS) drug discovery has mostly relied on traditional approaches of rodent models or cell-based in vitro models. Owing to the issues of species differences between humans and rodents, it is difficult to correlate the robustness of data for neurodevelopmental st...

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Bibliographische Detailangaben
Veröffentlicht in:Drug Discov Today
Hauptverfasser: Chhibber, Tanya, Bagchi, Sounak, Lahooti, Behnaz, Verma, Angela, Al-Ahmed, Abraham, Paul, Manash K., Pendyala, Gurudutt, Jayant, Rahul Dev
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039749/
https://ncbi.nlm.nih.gov/pubmed/31783130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2019.11.010
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