Topical cholesterol/lovastatin for the treatment of porokeratosis: a pathogenesis-directed therapy

BACKGROUND: Porokeratosis is associated with mevalonate pathway gene mutations. Therapeutic options are few and often limited in efficacy. OBJECTIVE: On the basis of preventing the accumulation of toxic metabolites while replenishing essential end-products, we studied the efficacy of topical lovasta...

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Veröffentlicht in:J Am Acad Dermatol
Hauptverfasser: Atzmony, Lihi, Lim, Young H., Hamilton, Claire, Leventhal, Jonathan S., Wagner, Annette, Paller, Amy S., Choate, Keith A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039698/
https://ncbi.nlm.nih.gov/pubmed/31449901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaad.2019.08.043
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