RT-QuIC-based detection of alpha-synuclein seeding activity in brains of dementia with Lewy Body patients and of a transgenic mouse model of synucleinopathy

RT-QuIC is a shaking-based cyclic amplification technique originally developed in the prion field to detect minute amounts of scrapie prion protein (PrP(Sc)). In this study, we applied the RT-QuIC assay to investigate a-synuclein (a-syn) seeding activity in brains of Dementia with Lewy Body (DLB) pa...

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Опубликовано в: :Prion
Главные авторы: Han, Jung-Youn, Jang, Hyung-Sup, Green, Alison J. E., Choi, Young Pyo
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2020
Предметы:
Short Communication
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7039666/
https://ncbi.nlm.nih.gov/pubmed/32041499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336896.2020.1724608
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