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Unbiased Estimation of Linkage Disequilibrium from Unphased Data

Linkage disequilibrium (LD) is used to infer evolutionary history, to identify genomic regions under selection, and to dissect the relationship between genotype and phenotype. In each case, we require accurate estimates of LD statistics from sequencing data. Unphased data present a challenge because...

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Bibliografiske detaljer
Udgivet i:Mol Biol Evol
Main Authors: Ragsdale, Aaron P, Gravel, Simon
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038669/
https://ncbi.nlm.nih.gov/pubmed/31697386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molbev/msz265
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