High-Dose Chloroquine for Uncomplicated Plasmodium falciparum Malaria Is Well Tolerated and Causes Similar QT Interval Prolongation as Standard-Dose Chloroquine in Children

Higher chloroquine doses can effectively treat up to 93 to 96% of malaria infections caused by Plasmodium falciparum carrying the resistance-conferring chloroquine resistance transporter (pfcrt) 76T allele. The tolerability of 50 (double the standard dose) and 70 mg/kg total chloroquine doses were a...

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Detaylı Bibliyografya
Yayımlandı:Antimicrob Agents Chemother
Asıl Yazarlar: Ursing, Johan, Rombo, Lars, Eksborg, Staffan, Larson, Lena, Bruvoll, Anita, Tarning, Joel, Rodrigues, Amabelia, Kofoed, Poul-Erik
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2020
Konular:
Clinical Therapeutics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038251/
https://ncbi.nlm.nih.gov/pubmed/31907183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01846-19
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