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Design, Synthesis, and Evaluation of Acetylcholinesterase and Butyrylcholinesterase Dual-Target Inhibitors against Alzheimer’s Diseases

A series of novel compounds 6a–h, 8i–1, 10s–v, and 16a–d were synthesized and evaluated, together with the known analogs 11a–f, for their inhibitory activities towards acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The inhibitory activities of AChE and BChE were evaluated in vitro by...

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Bibliografske podrobnosti
izdano v:Molecules
Main Authors: Guo, Yan, Yang, Hongyu, Huang, Zhongwei, Tian, Sen, Li, Qihang, Du, Chenxi, Chen, Tingkai, Liu, Yang, Sun, Haopeng, Liu, Zongliang
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7038160/
https://ncbi.nlm.nih.gov/pubmed/31979317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25030489
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