Reduced miR-26b Expression in Megakaryocytes and Platelets Contributes to Elevated Level of Platelet Activation Status in Sepsis

In sepsis, platelets may become activated via toll-like receptors (TLRs), causing microvascular thrombosis. Megakaryocytes (MKs) also express these receptors; thus, severe infection may modulate thrombopoiesis. To explore the relevance of altered miRNAs in platelet activation upon sepsis, we first i...

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Bibliografiske detaljer
Udgivet i:Int J Mol Sci
Main Authors: Szilágyi, Bernadett, Fejes, Zsolt, Póliska, Szilárd, Pócsi, Marianna, Czimmerer, Zsolt, Patsalos, Andreas, Fenyvesi, Ferenc, Rusznyák, Ágnes, Nagy, György, Kerekes, György, Berhés, Mariann, Szűcs, Ildikó, Kunapuli, Satya P., Kappelmayer, János, Nagy, Béla
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7036890/
https://ncbi.nlm.nih.gov/pubmed/32013235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21030866
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