Elucidating Binding Sites and Affinities of ERα Agonists and Antagonists to Human Alpha-Fetoprotein by In Silico Modeling and Point Mutagenesis

Alpha-fetoprotein (AFP) is a major embryo- and tumor-associated protein capable of binding and transporting a variety of hydrophobic ligands, including estrogens. AFP has been shown to inhibit estrogen receptor (ER)-positive tumor growth, which can be attributed to its estrogen-binding ability. Desp...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Moldogazieva, Nurbubu T., Ostroverkhova, Daria S., Kuzmich, Nikolai N., Kadochnikov, Vladimir V., Terentiev, Alexander A., Porozov, Yuri B.
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7036865/
https://ncbi.nlm.nih.gov/pubmed/32019136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21030893
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