A Lytic Polysaccharide Monooxygenase-like protein functions in fungal copper import and meningitis

Infection by the fungal pathogen Cryptococcus neoformans causes lethal meningitis, primarily in immune-compromised individuals. Colonization of the brain by C. neoformans is dependent on copper (Cu) acquisition from the host, which drives critical virulence mechanisms. While C. neoformans Cu(+) impo...

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I publikationen:Nat Chem Biol
Huvudupphovsmän: Garcia-Santamarina, Sarela, Probst, Corinna, Festa, Richard A., Ding, Chen, Smith, Aaron D., Conklin, Steven E., Brander, Søren, Kinch, Lisa N., Grishin, Nick V., Franz, Katherine J., Riggs-Gelasco, Pamela, Leggio, Leila Lo, Johansen, Katja Salomon, Thiele, Dennis J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7036007/
https://ncbi.nlm.nih.gov/pubmed/31932719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0437-9
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