Sustained hyperammonemia induces TNF-a IN Purkinje neurons by activating the TNFR1-NF-κB pathway

BACKGROUND: Patients with liver cirrhosis may develop hepatic encephalopathy. Rats with chronic hyperammonemia exhibit neurological alterations mediated by peripheral inflammation and neuroinflammation. Motor incoordination is due to increased TNF-a levels and activation of its receptor TNFR1 in the...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Balzano, Tiziano, Arenas, Yaiza M., Dadsetan, Sherry, Forteza, Jerónimo, Gil-Perotin, Sara, Cubas-Nuñez, Laura, Casanova, Bonaventura, Gracià, Francisco, Varela-Andrés, Natalia, Montoliu, Carmina, Llansola, Marta, Felipo, Vicente
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035786/
https://ncbi.nlm.nih.gov/pubmed/32087723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01746-z
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