Kv2.1 channels play opposing roles in regulating membrane potential, Ca(2+) channel function, and myogenic tone in arterial smooth muscle

The accepted role of the protein Kv2.1 in arterial smooth muscle cells is to form K(+) channels in the sarcolemma. Opening of Kv2.1 channels causes membrane hyperpolarization, which decreases the activity of L-type Ca(V)1.2 channels, lowering intracellular Ca(2+) ([Ca(2+)](i)) and causing smooth mus...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: O’Dwyer, Samantha C., Palacio, Stephanie, Matsumoto, Collin, Guarina, Laura, Klug, Nicholas R., Tajada, Sendoa, Rosati, Barbara, McKinnon, David, Trimmer, James S., Santana, L. Fernando
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035623/
https://ncbi.nlm.nih.gov/pubmed/32015129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1917879117
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