Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood–brain barrier

Drug targeting to inflammatory brain pathologies such as stroke and traumatic brain injury remains an elusive goal. Using a mouse model of acute brain inflammation induced by local tumor necrosis factor alpha (TNFα), we found that uptake of intravenously injected antibody to vascular cell adhesion m...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Marcos-Contreras, Oscar A., Greineder, Colin F., Kiseleva, Raisa Yu, Parhiz, Hamideh, Walsh, Landis R., Zuluaga-Ramirez, Viviana, Myerson, Jacob W., Hood, Elizabeth D., Villa, Carlos H., Tombacz, Istvan, Pardi, Norbert, Seliga, Alecia, Mui, Barbara L., Tam, Ying K., Glassman, Patrick M., Shuvaev, Vladimir V., Nong, Jia, Brenner, Jacob S., Khoshnejad, Makan, Madden, Tom, Weissmann, Drew, Persidsky, Yuri, Muzykantov, Vladimir R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
Soggetti:
Physical Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035611/
https://ncbi.nlm.nih.gov/pubmed/32005712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1912012117
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