Glioblastomas exploit truncated O-linked glycans for local and distant immune modulation via the macrophage galactose-type lectin

Glioblastoma is the most aggressive brain malignancy, for which immunotherapy has failed to prolong survival. Glioblastoma-associated immune infiltrates are dominated by tumor-associated macrophages and microglia (TAMs), which are key mediators of immune suppression and resistance to immunotherapy....

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Dusoswa, Sophie A., Verhoeff, Jan, Abels, Erik, Méndez-Huergo, Santiago P., Croci, Diego O., Kuijper, Lisan H., de Miguel, Elena, Wouters, Valerie M. C. J., Best, Myron G., Rodriguez, Ernesto, Cornelissen, Lenneke A. M., van Vliet, Sandra J., Wesseling, Pieter, Breakefield, Xandra O., Noske, David P., Würdinger, Thomas, Broekman, Marike L. D., Rabinovich, Gabriel A., van Kooyk, Yvette, Garcia-Vallejo, Juan J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035608/
https://ncbi.nlm.nih.gov/pubmed/32019882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1907921117
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