Elongation factor-Tu can repetitively engage aminoacyl-tRNA within the ribosome during the proofreading stage of tRNA selection

The substrate for ribosomes actively engaged in protein synthesis is a ternary complex of elongation factor Tu (EF-Tu), aminoacyl-tRNA (aa-tRNA), and GTP. EF-Tu plays a critical role in mRNA decoding by increasing the rate and fidelity of aa-tRNA selection at each mRNA codon. Here, using three-color...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Morse, Justin C., Girodat, Dylan, Burnett, Benjamin J., Holm, Mikael, Altman, Roger B., Sanbonmatsu, Karissa Y., Wieden, Hans-Joachim, Blanchard, Scott C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035488/
https://ncbi.nlm.nih.gov/pubmed/32024753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1904469117
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