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M2 amphipathic helices facilitate pH-dependent conformational transition in influenza A virus
The matrix-2 (M2) protein from influenza A virus is a tetrameric, integral transmembrane (TM) protein that plays a vital role in viral replication by proton flux into the virus. The His37 tetrad is a pH sensor in the center of the M2 TM helix that activates the channel in response to the low endosom...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7035486/ https://ncbi.nlm.nih.gov/pubmed/32015120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913385117 |
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