UHRF1-repressed 5’-hydroxymethylcytosine is essential for the male meiotic prophase I

5’-hydroxymethylcytosine (5hmC), an important 5’-cytosine modification, is altered highly in order in male meiotic prophase. However, the regulatory mechanism of this dynamic change and the function of 5hmC in meiosis remain largely unknown. Using a knockout mouse model, we showed that UHRF1 regulat...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Pan, Hongjie, Jiang, Ning, Sun, Shenfei, Jiang, Hanwei, Xu, Jianze, Jiang, Xiaohua, Gao, Qian, Li, Liang, Wu, Haili, Zheng, Huajun, Qi, Qi, Li, Tianqi, Zhang, Meixing, Zhang, Lingling, Wan, Xiaofeng, Lin, Xinhua, Wong, Jiemin, Shi, Qinghua, Li, Runsheng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035279/
https://ncbi.nlm.nih.gov/pubmed/32081844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2333-3
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