High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus

OBJECTIVES: To investigate associations between a high genetic disease risk and disease severity in patients with systemic lupus erythematosus (SLE). METHODS: Patients with SLE (n=1001, discovery cohort and n=5524, replication cohort) and healthy controls (n=2802 and n=9859) were genotyped using a 2...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Ann Rheum Dis
المؤلفون الرئيسيون: Reid, Sarah, Alexsson, Andrei, Frodlund, Martina, Morris, David, Sandling, Johanna K, Bolin, Karin, Svenungsson, Elisabet, Jönsen, Andreas, Bengtsson, Christine, Gunnarsson, Iva, Illescas Rodriguez, Vera, Bengtsson, Anders, Arve, Sabine, Rantapää-Dahlqvist, Solbritt, Eloranta, Maija-Leena, Syvänen, Ann-Christine, Sjöwall, Christopher, Vyse, Timothy James, Rönnblom, Lars, Leonard, Dag
التنسيق: Artigo
اللغة:Inglês
منشور في: BMJ Publishing Group 2020
الموضوعات:
Systemic Lupus Erythematosus
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC7034364/
https://ncbi.nlm.nih.gov/pubmed/31826855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2019-216227
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