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6mer Seed Toxicity in Viral microRNAs
MicroRNAs (miRNAs) are short double-stranded noncoding RNAs (19-23 nucleotides) that regulate gene expression by suppressing mRNAs through RNA interference. Targeting is determined by the seed sequence (position 2-7/8) of the mature miRNA. A minimal G-rich seed of just six nucleotides is highly toxi...
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| Pubblicato in: | iScience |
|---|---|
| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7033618/ https://ncbi.nlm.nih.gov/pubmed/31838022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.11.031 |
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