Pharmacokinetics of TKM-130803 in Sierra Leonean patients with Ebola virus disease:  plasma concentrations exceed target levels, with drug accumulation in the most severe patients

BACKGROUND: TKM-130803 is a specific anti-EBOV therapeutic comprised of two small interfering RNAs (siRNA) siLpol-2 and siVP35-2. The pharmacokinetics (PK) of these siRNAs was defined in Ebola virus disease (EVD) patients, with reference to efficacy (ET) and toxicology thresholds (TT). The relations...

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Veröffentlicht in:EBioMedicine
Hauptverfasser: Scott, Janet T., Sharma, Raman, Meredith, Luke W., Dunning, Jake, Moore, Catrin E., Sahr, Foday, Ward, Steve, Goodfellow, Ian, Horby, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
Schlagworte:
Research paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7033524/
https://ncbi.nlm.nih.gov/pubmed/31953031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.102601
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