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A new role for an old cytokine: GM-CSF amplifies GVHD
In this issue of Blood, Piper et al find that donor T cells that secrete granulocyte-macrophage colony-stimulating factor (GM-CSF) promote graft-versus-host disease (GVHD) by recruiting donor dendritic cells.(1) This amplifies the activation of alloreactive T cells and increases the severity of GVHD...
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| Pubblicato in: | Blood |
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| Autore principale: | |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7033371/ https://ncbi.nlm.nih.gov/pubmed/32078687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019004681 |
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