Ablation of Myeloid Cell MRP8 Ameliorates Nephrotoxic Serum-induced Glomerulonephritis by Affecting Macrophage Characterization through Intraglomerular Crosstalk

Toll-like receptor 4 (TLR4) and one of its endogenous ligands myeloid-related protein 8 (MRP8 or S100A8), especially expressed in macrophages, play an important role in diabetic nephropathy and autoimmune disorders. However, detailed mechanisms and consequence of MRP8 expression remain unknown, part...

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Publicado no:Sci Rep
Main Authors: Hata, Yusuke, Kuwabara, Takashige, Mori, Kiyoshi, Kan, Youngna, Sato, Yuki, Umemoto, Shuro, Fujimoto, Daisuke, Kanki, Tomoko, Nishiguchi, Yoshihiko, Yokoi, Hideki, Kakizoe, Yutaka, Izumi, Yuichiro, Yanagita, Motoko, Mukoyama, Masashi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7033179/
https://ncbi.nlm.nih.gov/pubmed/32080297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59970-9
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