Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

Endosomal sequestration of lipid-based nanoparticles (LNPs) remains a formidable barrier to delivery. Herein, structure-activity analysis of cholesterol analogues reveals that incorporation of C-24 alkyl phytosterols into LNPs (eLNPs) enhances gene transfection and the length of alkyl tail, flexibil...

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Udgivet i:Nat Commun
Main Authors: Patel, Siddharth, Ashwanikumar, N., Robinson, Ema, Xia, Yan, Mihai, Cosmin, Griffith, Joseph P., Hou, Shangguo, Esposito, Adam A., Ketova, Tatiana, Welsher, Kevin, Joyal, John L., Almarsson, Örn, Sahay, Gaurav
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7033178/
https://ncbi.nlm.nih.gov/pubmed/32080183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14527-2
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