Ultra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy

Paclitaxel is widely used in cancer treatments, but poor water-solubility and toxicity raise serious concerns. Here we report an RNA four-way junction nanoparticle with ultra-thermodynamic stability to solubilize and load paclitaxel for targeted cancer therapy. Each RNA nanoparticle covalently loads...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Guo, Sijin, Vieweger, Mario, Zhang, Kaiming, Yin, Hongran, Wang, Hongzhi, Li, Xin, Li, Shanshan, Hu, Shuiying, Sparreboom, Alex, Evers, B. Mark, Dong, Yizhou, Chiu, Wah, Guo, Peixuan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7033104/
https://ncbi.nlm.nih.gov/pubmed/32080195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14780-5
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