Autism risk in offspring can be assessed through quantification of male sperm mosaicism

De novo mutations (DNMs) arising on the paternal chromosome make the largest known contribution to autism risk, and correlate with paternal age at the time of conception. The recurrence risk for autism spectrum disorders (ASD) is substantial, leading many families to decline future pregnancies, but...

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Detalhes bibliográficos
Publicado no:Nat Med
Main Authors: Breuss, Martin W., Antaki, Danny, George, Renee D., Kleiber, Morgan, James, Kiely N., Ball, Laurel L., Hong, Oanh, Mitra, Ileena, Yang, Xiaoxu, Wirth, Sara A., Gu, Jing, Garcia, Camila A. B., Gujral, Madhusudan, Brandler, William M., Musaev, Damir, Nguyen, An, McEvoy-Venneri, Jennifer, Knox, Renatta, Sticca, Evan, Botello, Martha Cristina Cancino, Fenner, Javiera Uribe, Pérez, Maria Cárcel, Arranz, Maria, Moffitt, Andrea B., Wang, Zihua, Hervás, Amaia, Devinsky, Orrin, Gymrek, Melissa, Sebat, Jonathan, Gleeson, Joseph G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7032648/
https://ncbi.nlm.nih.gov/pubmed/31873310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-019-0711-0
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