Vitamin E sequestration by liver fat in humans

BACKGROUND: We hypothesized that obesity-associated hepatosteatosis is a pathophysiological chemical depot for fat-soluble vitamins and altered normal physiology. Using α-tocopherol (vitamin E) as a model vitamin, pharmacokinetics and kinetics principles were used to determine whether excess liver f...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Violet, Pierre-Christian, Ebenuwa, Ifechukwude C., Wang, Yu, Niyyati, Mahtab, Padayatty, Sebastian J., Head, Brian, Wilkins, Kenneth, Chung, Stacey, Thakur, Varsha, Ulatowski, Lynn, Atkinson, Jeffrey, Ghelfi, Mikel, Smith, Sheila, Tu, Hongbin, Bobe, Gerd, Liu, Chia-Ying, Herion, David W., Shamburek, Robert D., Manor, Danny, Traber, Maret G., Levine, Mark
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7030816/
https://ncbi.nlm.nih.gov/pubmed/31821172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.133309
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