PLAGL2 promotes epithelial–mesenchymal transition and mediates colorectal cancer metastasis via β-catenin-dependent regulation of ZEB1

BACKGROUND: We previously demonstrated that the pleomorphic adenoma gene like-2 (PLAGL2) is involved in the pathogenesis of Hirschsprung disease. Enhanced PLAGL2 expression was observed in several malignant tumours. However, the exact function of PLAGL2 and its underlying mechanism in colorectal can...

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Bibliographic Details
Published in:Br J Cancer
Main Authors: Wu, Liang, Zhou, Zili, Han, Shengbo, Chen, Jinhuang, Liu, Zhengyi, Zhang, Xudan, Yuan, Wenzheng, Ji, Jintong, Shu, Xiaogang
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028997/
https://ncbi.nlm.nih.gov/pubmed/31827238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0679-z
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