Intra-islet GLP-1, but not CCK, is necessary for β-cell function in mouse and human islets

Glucagon-like peptide 1 (GLP-1) and cholecystokinin (CCK) are gut-derived peptide hormones known to play important roles in the regulation of gastrointestinal motility and secretion, appetite, and food intake. We have previously demonstrated that both GLP-1 and CCK are produced in the endocrine panc...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: de Souza, Arnaldo Henrique, Tang, Jiayin, Yadev, Amanjot Kaur, Saghafi, Samuel T., Kibbe, Carly R., Linnemann, Amelia K., Merrins, Matthew J., Davis, Dawn Belt
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028949/
https://ncbi.nlm.nih.gov/pubmed/32071395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59799-2
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