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Repurposing screen identifies mebendazole as a clinical candidate to synergise with docetaxel for prostate cancer treatment

BACKGROUND: Docetaxel chemotherapy in prostate cancer has a modest impact on survival. To date, efforts to develop combination therapies have not translated into new treatments. We sought to develop a novel therapeutic strategy to tackle chemoresistant prostate cancer by enhancing the efficacy of do...

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Détails bibliographiques
Publié dans:Br J Cancer
Auteurs principaux: Rushworth, Linda K., Hewit, Kay, Munnings-Tomes, Sophie, Somani, Sukrut, James, Daniel, Shanks, Emma, Dufès, Christine, Straube, Anne, Patel, Rachana, Leung, Hing Y.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028732/
https://ncbi.nlm.nih.gov/pubmed/31844184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0681-5
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