T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources

Chimeric antigen receptor (CAR) T-cells have shown great promise in the treatment of B-cell malignancies. For acute myeloid leukemia (AML), however, the optimal target surface antigen has yet to be discovered. Alternatively, T-cell receptor (TCR)-redirected T-cells target intracellular antigens, mar...

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Vydáno v:Oncoimmunology
Hlavní autoři: Bonte, Sarah, De Munter, Stijn, Goetgeluk, Glenn, Ingels, Joline, Pille, Melissa, Billiet, Lore, Taghon, Tom, Leclercq, Georges, Vandekerckhove, Bart, Kerre, Tessa
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2020
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028335/
https://ncbi.nlm.nih.gov/pubmed/32117593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2020.1727078
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