The role of metabolism in the developmental toxicity of polycyclic aromatic hydrocarbon‐containing extracts of petroleum substances

In vitro assays presently used for prenatal developmental toxicity (PDT) testing only assess the embryotoxic potential of parent substances and not that of potentially embryotoxic metabolites. Here we combined a biotransformation system, using hamster liver microsomes, with the ES‐D3 cell differenti...

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Vydáno v:J Appl Toxicol
Hlavní autoři: Kamelia, Lenny, de Haan, Laura, Spenkelink, Bert, Bruyneel, Ben, Ketelslegers, Hans B., Boogaard, Peter J., Rietjens, Ivonne M.C.M.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028058/
https://ncbi.nlm.nih.gov/pubmed/31808176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jat.3906
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