Evaluating the safety and potential activity of URO‐902 (hMaxi‐K) gene transfer by intravesical instillation or direct injection into the bladder wall in female participants with idiopathic (non‐neurogenic) overactive bladder syndrome and detrusor overactivity from two double‐blind, imbalanced, placebo‐controlled randomized phase 1 trials

AIMS: Two phase 1 trials were performed in healthy women with the overactive bladder (OAB) syndrome and urodynamically demonstrated detrusor overactivity (DO), with the aim to demonstrate the safety and potential efficacy of URO‐902, which comprises a gene therapy plasmid vector expressing the human...

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Detalhes bibliográficos
Publicado no:Neurourol Urodyn
Main Authors: Rovner, Eric, Chai, Toby C., Jacobs, Sharon, Christ, George, Andersson, Karl‐Erik, Efros, Mitchell, Nitti, Victor, Davies, Kelvin, McCullough, Andrew R., Melman, Arnold
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Clinical Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7028015/
https://ncbi.nlm.nih.gov/pubmed/31945197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/nau.24272
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