Zerumbone ameliorates behavioral impairments and neuropathology in transgenic APP/PS1 mice by suppressing MAPK signaling

BACKGROUND: Alzheimer’s disease (AD) is a major clinical problem, but there is a distinct lack of effective therapeutic drugs for this disease. We investigated the potential therapeutic effects of zerumbone, a subtropical ginger sesquiterpene, in transgenic APP/PS1 mice, rodent models of AD which ex...

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Dettagli Bibliografici
Pubblicato in:J Neuroinflammation
Autori principali: Li, Lei, Wu, Xiang-Hui, Zhao, Xiao-Jing, Xu, Lu, Pan, Cai-Long, Zhang, Zhi-Yuan
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7027354/
https://ncbi.nlm.nih.gov/pubmed/32066466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01744-1
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