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Triheptanoin alters [U-(13)C(6)]-glucose incorporation into glycolytic intermediates and increases TCA cycling by normalizing the activities of pyruvate dehydrogenase and oxoglutarate dehydrogenase in a chronic epilepsy mouse model

Triheptanoin is anticonvulsant in several seizure models. Here, we investigated changes in glucose metabolism by triheptanoin interictally in the chronic stage of the pilocarpine mouse epilepsy model. After injection of [U-(13)C(6)]-glucose (i.p.), enrichments of (13)C in intermediates of glycolysis...

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Bibliografiske detaljer
Udgivet i:J Cereb Blood Flow Metab
Main Authors: McDonald, Tanya, Hodson, Mark P, Bederman, Ilya, Puchowicz, Michelle, Borges, Karin
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7026856/
https://ncbi.nlm.nih.gov/pubmed/30890077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X19837380
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