Excitatory pathway engaging glutamate, calcineurin, and NFAT upregulates IL-4 in ischemic neurons to polarize microglia

Excitotoxicity and microglia/macrophage over-activation are the important pathogenic steps in brain damage caused by ischemic stroke. Recent studies from our group suggest that the neurons in ischemic penumbra generate an anti-inflammatory cytokine, interleukin-4 (IL-4). This neuron-produced IL-4 co...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:J Cereb Blood Flow Metab
Huvudupphovsmän: Ting, Shun-Ming, Zhao, Xiurong, Zheng, Xueping, Aronowski, Jaroslaw
Materialtyp: Artigo
Språk:Inglês
Publicerad: SAGE Publications 2019
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7026849/
https://ncbi.nlm.nih.gov/pubmed/30890073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X19838189
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk