Mboat7 down-regulation by hyper-insulinemia induces fat accumulation in hepatocytes

BACKGROUND: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), encoding for an enzyme involved in phosphatidylinositol acyl-chain remodelling, has been associated with fatty liver and hepatic disorders. Here, we examined the relationship between hepatic M...

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Udgivet i:EBioMedicine
Main Authors: Meroni, Marica, Dongiovanni, Paola, Longo, Miriam, Carli, Fabrizia, Baselli, Guido, Rametta, Raffaela, Pelusi, Serena, Badiali, Sara, Maggioni, Marco, Gaggini, Melania, Fracanzani, Anna Ludovica, Romeo, Stefano, Gatti, Stefano, Davidson, Nicholas O., Gastaldelli, Amalia, Valenti, Luca
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
Fag:
Research paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7026742/
https://ncbi.nlm.nih.gov/pubmed/32058943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102658
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