Sensitive CometChip assay for screening potentially carcinogenic DNA adducts by trapping DNA repair intermediates

Genotoxicity testing is critical for predicting adverse effects of pharmaceutical, industrial, and environmental chemicals. The alkaline comet assay is an established method for detecting DNA strand breaks, however, the assay does not detect potentially carcinogenic bulky adducts that can arise when...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Ngo, Le P, Owiti, Norah A, Swartz, Carol, Winters, John, Su, Yang, Ge, Jing, Xiong, Aoli, Han, Jongyoon, Recio, Leslie, Samson, Leona D, Engelward, Bevin P
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Methods Online
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7026589/
https://ncbi.nlm.nih.gov/pubmed/31822921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1077
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