Effects of vedolizumab in Japanese patients with Crohn’s disease: a prospective, multicenter, randomized, placebo-controlled Phase 3 trial with exploratory analyses

BACKGROUND: Vedolizumab is a gut-selective humanized antibody that binds the α(4)β(7) integrin. We evaluated efficacy and safety of vedolizumab in Japanese patients with moderate-to-severe Crohn’s disease (CD). METHODS: In this Phase 3, double-blind study (NCT02038920), 157 patients were randomized...

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Detalhes bibliográficos
Publicado no:J Gastroenterol
Main Authors: Watanabe, Kenji, Motoya, Satoshi, Ogata, Haruhiko, Kanai, Takanori, Matsui, Toshiyuki, Suzuki, Yasuo, Shikamura, Mitsuhiro, Sugiura, Kenkichi, Oda, Kazunori, Hori, Tetsuharu, Araki, Takahiro, Watanabe, Mamoru, Hibi, Toshifumi
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Singapore 2019
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Original Article—Alimentary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7026209/
https://ncbi.nlm.nih.gov/pubmed/31836930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00535-019-01647-w
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