5-Nitrouracil stabilizes the plasma concentration values of 5-FU in colorectal cancer patients receiving capecitabine

Capecitabine is selectively converted from 5′-DFUR to 5-fluorouracil (5-FU) in tumours by thymidine phosphorylase (TP). We investigated the addition of 5-nitrouracil (5-NU), a TP inhibitor, into blood samples for precise measurements of plasma 5-FU concentrations. The plasma concentration of 5-FU wa...

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Publicado en:Sci Rep
Main Authors: Yoshida, Yoichiro, Hashimoto, Yasuhiro, Miyazaki, Makoto, Aisu, Naoya, Yamada, Teppei, Kajitani, Ryuji, Munechika, Taro, Matsumoto, Yoshiko, Nagano, Hideki, Shimaoka, Hideki, Komono, Akira, Sakamoto, Ryohei, Yoshimatsu, Gumpei, Yoshimura, Fumihiro, Kiyomi, Fumiaki, Hasegawa, Suguru
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7026090/
https://ncbi.nlm.nih.gov/pubmed/32066801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-59648-2
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