Essential role of microglial transforming growth factor-β1 in antidepressant actions of (R)-ketamine and the novel antidepressant TGF-β1

In rodent models of depression, (R)-ketamine has greater potency and longer-lasting antidepressant effects than (S)-ketamine; however, the precise molecular mechanisms underlying the antidepressant actions of (R)-ketamine remain unknown. Using RNA-sequencing analysis, we identified novel molecular t...

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Vydáno v:Transl Psychiatry
Hlavní autoři: Zhang, Kai, Yang, Chun, Chang, Lijia, Sakamoto, Akemi, Suzuki, Toru, Fujita, Yuko, Qu, Youge, Wang, Siming, Pu, Yaoyu, Tan, Yunfei, Wang, Xingming, Ishima, Tamaki, Shirayama, Yukihiko, Hatano, Masahiko, Tanaka, Kenji F., Hashimoto, Kenji
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7026089/
https://ncbi.nlm.nih.gov/pubmed/32066676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-020-0733-x
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