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Cyclophilin D Contributes to Anesthesia Neurotoxicity in the Developing Brain

Anesthetic sevoflurane induces mitochondrial dysfunction, impairment of neurogenesis, and cognitive impairment in young mice, but the underlying mechanism remains to be determined. Cyclophilin D (CypD) is a modulatory factor for the mitochondrial permeability transition pore (mPTP). We, therefore, s...

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Publicado en:Front Cell Dev Biol
Autores principales: Zhang, Yiying, Lu, Pan, Liang, Feng, Liufu, Ning, Dong, Yuanlin, Zheng, Jialin Charles, Xie, Zhongcong
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7026027/
https://ncbi.nlm.nih.gov/pubmed/32117955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2019.00396
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