Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors

[Image: see text] Inhibition of neprilysin (NEP) is widely studied as a therapeutic target for the treatment of hypertension, heart failure, and kidney disease. Sacubitril/valsartan (LCZ696) is a drug approved to reduce the risk of cardiovascular death in heart failure patients with reduced ejection...

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Argitaratua izan da:ACS Med Chem Lett
Egile Nagusiak: Kawanami, Toshio, Karki, Rajeshri G., Cody, Emma, Liu, Qian, Liang, Guiqing, Ksander, Gary M., Rigel, Dean F., Schiering, Nikolaus, Gong, Yongjin, Coppola, Gary M., Iwaki, Yuki, Sun, Robert, Neubert, Alan, Fan, Li, Ingles, Sara, D’Arcy, Allan, Villard, Frederic, Ramage, Paul, Jeng, Arco Y., Leung-Chu, Jennifer, Liu, Jing, Beil, Michael, Fu, Fumin, Chen, Wei, Cumin, Frederic, Wiesmann, Christian, Mogi, Muneto
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2020
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7025385/
https://ncbi.nlm.nih.gov/pubmed/32071687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00578
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