A proof‐of‐concept, Phase 2 clinical trial of the gastrointestinal safety of a hydrogen sulfide‐releasing anti‐inflammatory drug

BACKGROUND AND PURPOSE: ATB‐346 is a hydrogen sulfide (H(2)S)‐releasing anti‐inflammatory and analgesic drug. Animal studies demonstrated negligible gastrointestinal (GI) damage despite marked inhibition of COX activity and significant analgesic and anti‐inflammatory effects. In humans, ATB‐346 (250...

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Udgivet i:Br J Pharmacol
Main Authors: Wallace, John L., Nagy, Peter, Feener, Troy D., Allain, Thibault, Ditrói, Tamás, Vaughan, David J., Muscara, Marcelo N., de Nucci, Gilberto, Buret, Andre G.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Themed Section: Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7024706/
https://ncbi.nlm.nih.gov/pubmed/30834513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14641
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