HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor in Clear Cell Renal Cell Carcinoma Patients

PURPOSE: The heterodimeric transcription factor HIF-2 is arguably the most important driver of clear cell renal cell carcinoma (ccRCC). While considered undruggable, structural analyses at UT Southwestern Medical Center (UTSW) identified a vulnerability in the α subunit, which heterodimerizes with H...

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Publicado no:Clin Cancer Res
Main Authors: Courtney, Kevin D., Ma, Yuanqing, de Leon, Alberto Diaz, Christie, Alana, Xie, Zhiqun, Woolford, Layton, Singla, Nirmish, Joyce, Allison, Hill, Haley, Madhuranthakam, Ananth J., Yuan, Qing, Xi, Yin, Zhang, Yue, Chang, Jenny, Fatunde, Oluwatomilade, Arriaga, Yull, Frankel, Arthur, Kalva, Sanjeeva, Zhang, Song, McKenzie, Tiffani, Torras, Oscar Reig, Figlin, Robert A., Rini, Brian I., McKay, Renée M., Kapur, Payal, Wang, Tao, Pedrosa, Ivan, Brugarolas, James
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7024660/
https://ncbi.nlm.nih.gov/pubmed/31727677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-1459
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