Structure-Based Virtual Screening, Molecular Dynamics and Binding Free Energy Calculations of Hit Candidates as ALK-5 Inhibitors

Activin-like kinase 5 (ALK-5) is involved in the physiopathology of several conditions, such as pancreatic carcinoma, cervical cancer and liver hepatoma. Cellular events that are landmarks of tumorigenesis, such as loss of cell polarity and acquisition of motile properties and mesenchymal phenotype,...

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Publicado en:Molecules
Main Authors: Araujo, Sheila C., Maltarollo, Vinicius G., Almeida, Michell O., Ferreira, Leonardo L. G., Andricopulo, Adriano D., Honorio, Kathia M.
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7024315/
https://ncbi.nlm.nih.gov/pubmed/31936488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25020264
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