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Rho-mediated signaling promotes BRAF inhibitor resistance in de-differentiated melanoma cells
Over half of cutaneous melanoma tumors have BRAF(V600E/K) mutations. Acquired resistance to BRAF inhibitors (BRAFi) remains a major hurdle in attaining durable therapeutic responses. In this study we demonstrate that approximately 50–60% of melanoma cell lines with vemurafenib resistance acquired in...
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| Udgivet i: | Oncogene |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7024013/ https://ncbi.nlm.nih.gov/pubmed/31659259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-1074-1 |
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