Structural basis of second-generation HIV integrase inhibitor action and viral resistance

Although second-generation HIV integrase strand-transfer inhibitors (INSTIs) are prescribed throughout the world, the mechanistic basis for the superiority of these drugs is poorly understood. We used single-particle cryo–electron microscopy to visualize the mode of action of the advanced INSTIs dol...

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Bibliografske podrobnosti
izdano v:Science
Main Authors: Cook, Nicola J., Li, Wen, Berta, Dénes, Badaoui, Magd, Ballandras-Colas, Allison, Nans, Andrea, Kotecha, Abhay, Rosta, Edina, Engelman, Alan N., Cherepanov, Peter
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7023979/
https://ncbi.nlm.nih.gov/pubmed/32001525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aay4919
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