Chemoenzymatic Synthesis of Enantiomeric, Bicyclic δ-Halo-γ-lactones with a Cyclohexane Ring, Their Biological Activity and Interaction with Biological Membranes

Starting from 1-acetyl-1-cyclohexene, three enantiomeric pairs (ee ≥ 99%) of bicyclic δ-halo-γ-lactones with cyclohexane ring were obtained in five-step synthesis. The key stereochemical steps were lipase-catalyzed kinetic resolution of racemic 1-(cyclohex-1-en-1-yl) ethanol followed by transfer of...

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Vydáno v:Biomolecules
Hlavní autoři: Mazur, Marcelina, Włoch, Aleksandra, Bahri, Fouad, Pruchnik, Hanna, Pawlak, Aleksandra, Obmińska-Mrukowicz, Bożena, Maciejewska, Gabriela, Gładkowski, Witold
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022392/
https://ncbi.nlm.nih.gov/pubmed/31935977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10010095
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