Dispersibility and Storage Stability Optimization of High Dose Isoniazid Dry Powder Inhalation Formulations with L-Leucine or Trileucine

Tuberculosis is the leading cause of death from a single infectious pathogen worldwide. Lately, the targeted delivery of antibiotics to the lungs via inhalation has received increasing interest. In a previous article, we reported on the development of a spray-dried dry powder isoniazid formulation c...

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Bibliographic Details
Published in:Pharmaceutics
Main Authors: Sibum, Imco, Hagedoorn, Paul, Kluitman, Markus P. G., Kloezen, Martijn, Frijlink, Henderik W., Grasmeijer, Floris
Format: Artigo
Language:Inglês
Published: MDPI 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7022271/
https://ncbi.nlm.nih.gov/pubmed/31881695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12010024
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