Glutamatergic and dopaminergic function and the relationship to outcome in people at clinical high risk of psychosis: a multi-modal PET-magnetic resonance brain imaging study

Preclinical models of psychosis propose that hippocampal glutamatergic neuron hyperactivity drives increased striatal dopaminergic activity, which underlies the development of psychotic symptoms. The aim of this study was to examine the relationship between hippocampal glutamate and subcortical dopa...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Howes, Oliver D., Bonoldi, Ilaria, McCutcheon, Robert A., Azis, Matilda, Antoniades, Mathilde, Bossong, Matthijs, Modinos, Gemma, Perez, Jesus, Stone, James M., Santangelo, Barbara, Veronese, Mattia, Grace, Anthony, Allen, Paul, McGuire, Philip K.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7021794/
https://ncbi.nlm.nih.gov/pubmed/31618752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-019-0541-2
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