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Toxoplasma Cathepsin Protease B and Aspartyl Protease 1 Are Dispensable for Endolysosomal Protein Digestion

The lysosome-like vacuolar compartment (VAC) is a major site of proteolysis in the intracellular parasite Toxoplasma gondii. Previous studies have shown that genetic ablation of a VAC-residing cysteine protease, cathepsin protease L (CPL), resulted in the accumulation of undigested protein in the VA...

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Detalhes bibliográficos
Publicado no:mSphere
Main Authors: McDonald, Christian, Smith, David, Di Cristina, Manlio, Kannan, Geetha, Dou, Zhicheng, Carruthers, Vern B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7021471/
https://ncbi.nlm.nih.gov/pubmed/32051238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00869-19
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